Does Dexmedetomidine Protect the Visceral Organs against the Asphxia

Background: This study was conducted to determine whether dexmedetomidine exhibits a protective effect against sudden and short term hypoxia on brain, heart, lung, liver, and kidney in rat model which sudden hyperglycemia and hypertension developed. Methods: In this randomised and double blind study, the experiment was performed on 30 male Wistar Albino rats 250-300 g weight. The rats were randomly assigned into 2 groups which are control group (C, n = 15), and dexmedetomidine group (D, n = 15). All rats were made hyperglycemic by a single injection of streptozotocin (STZ) (50 mg/kg) then, adrenalin (0.03 mg/kg) was injected intraperitonealy to make sudden hypertension. Dexmedetomidine (10 µg/kg/min, total dose 2.5-3.3 µg) was infused intraperitonealy in group D, and saline to group C. They were sacrified until observing siyanosis on the feet and stopping the body movement.