Heat-Shock Proteins and their Role in the Adaptation of Living Organisms to the Environment Temperature

The adaptation mechanisms of animal and plant organisms to the temperature are considered. The polyamines, heatshock proteins and their synthesizing genes actively participate in it, by means of which as a result of their aggregation the endurance of living organisms to the temperature has been formed, which prevents the damage to the proteins in the nucleus and other organelles of the cell. The adaptation to high or low temperatures promotes the normal functioning of the peripheral and central nervous systems. In connection with this problem, we studied the thermo-stabilizing proteins of rats brain and found that this is neurolectin pH3 (40), the content of which was measured in the rat brain cerebral cortex, as well as its dependence on the temperature to which the animals were exposed to outdoors during 1 year. In May, the specific activity of neurolectin pH3 (40) in the cerebral cortex was 4 units, whereas in December, it was increased more than 37-times. The perspective of therapeutic use of heat-shock proteins in the treatment of malignant tumors is also considered.