SERUM C-PEPTIDE CONCENTRATIONS IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME (PCOS)

Background:Polycystic ovarian syndrome (PCOS) is a heterogenous endocrine disorder affecting majority of women in reproductive age. The major endocrine disruption being excessive androgen production and abnormal insulin activity. Excess body weight in women with PCOS accelerates progression towards diabetes by exacerbating both insulin resistance and inappropriate insulin response. As Insulin levels are related to C-peptide levels and as insulin resistance is key finding in PCOS women, increased serum insulin and serum C-Peptide concentrations are considered to be a major finding in PCOS. Methods:Its a case control study was carried out in Gitam institute of medical sciences and research hospital during june 2018 to august 2018 which includes 60 females aged between 17-29 years. Out of 60 female participants, 30 females were cases with PCOS and the remaining 30 were age matched apparently healthy females. Diagnosis of PCOS is based on 2 of 3 findings ? oligo/anovulation, hyperandrogenism, polycystic ovaries in ultrasound (Rotterdam criteria). Results:Serum C-peptide concentrations measured in cases and controls were analysed by SPSS statistical software 23.0. The means of C-peptide between case and control group were compared by unpaired student t-test. P value less than 0.05 were considered statistically significant. The mean ? SD of C-peptide in case group (women with PCOS) was 3.24?0.51 ng/ml which was significantly higher (P < 0.05) than mean of control group (women without PCOS). Conclusion:This study showed significantly higher serum C-peptide concentrations in women with PCOS confirming the presence of insulin resistance in PCOS women.