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Cost-Benefit Analysis: Hemopatch® Vs Standard of Care in The Incidence of Postoperative Pancreatic Fistula in a Observational Study

Journal: American Journal of Biomedical Science & Research (Vol.1, No. 1)

Publication Date:

Authors : ; ;

Page : 11-19

Keywords : Postoperative pancreatic fistula; Pancreaticoduodenectomy; Duct-to-mucosa pancreaticojejunostomy; Hemopatch;

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Objective: To determine the efficacy and the impact on postoperative morbidity, mortality, and direct hospitalization costs of using the hemostatic-sealant Hemopatch® in patients undergoing pancreaticoduodenectomy. Method: A retrospective observational data review (26 consecutive pancreaticoduodenectomies) from July 2015 to October 2016 using the same surgical technique, 13 procedures reinforcing the duct-to-mucosa pancreaticojejunostomy with Hemopatch® and 13 procedures without Hemopatch® at Miguel Servet University Hospital, Zaragoza, Spain. Both groups were statistically homogenous. Demographic data and rates of postoperative complications were collected. To extrapolate the average cost for pancreaticoduodenectomy treatment in a larger population with a normal distribution, a Monte Carlo simulation was run with a 1,000-procedure scenario. Results: Results of the Monte Carlo simulation determined: the incidence of postoperative pancreatic fistula in the Hemopatch® group reported was 7.7% vs 30.9% (p value: 0.05), biliary fistula 7.7% vs 15.4% (p value: 0.05), hemorrhage 7.7% vs 15.5% (p value: 0.05), mean stay 20.8 vs 26.3 days (p value: 0.01), ICU stay 7.1 vs 9.1 days (p value: 0.01). Therefore, improved outcomes of Hemopatch® vs SoC, respectively resulted in a cost offset of: ICU length of stay $16,254.18 vs $21,000.41, total hospital length of stay $13,659.92 vs $17,233.67 (excluding ICU stay), postoperative pancreatic fistula $427.90 vs $2,234.05 biliary fistula $1,119.21 vs $2,238.43 and hemorrhage $427.90 vs $855.80. Conclusions: Sealing with Hemopatch® as an adjuvant after a pancreaticoduodenectomy might offer a new possibility to decrease postoperative pancreatic fistula, with fewer severe fistulas, shorter hospital stays and reduced healthcare costs. The use of Hemopatch® resulted in a substantial savings of $10,592.00 (-23%) per patient. Hemopatch® might be an effective and cost-beneficial alternative against the standard of care

Last modified: 2019-05-03 16:24:15