The Effect of Antiphospholipid Antibodies on the Structure of the Placental Villi

Two placentas at term were obtained of two woman pregnancy with diagnostic of phospholipid syndrome who were treated by means of antithrombotic therapy using acetylsalicylic acid and heparin. Newborns were born alive. Normal placenta as control was taken. Of each placenta five small specimens were taken of the basal plate. Three slides by specimen were prepared for light microscopy and 45 histological slides in total were stained with H&E. Trophoblast suffered changes remarkable. This appears thinner, interrupted, in denudation, accumulations of syncytium are expelled toward intervillous space, fragments of villi are observed, villi with disorganized structure are seen affected by edema. Immature villi affected by these changes are dominant in these observations. Antiphospholipids, antibodies have produced persistent immaturity.