A Case of Oral leukoplakia Recovered by Receiving HRT for 3 Months | Biomed Grid

Eucoplakia is well known as a pre-malignant disease in oral tumour. About 80 years ago, hormone replacement therapy was useful for the treatment of oral leucoplakia. However, no report regarding efficacy of HRT has not been obtained since then.Case 48y female, past history: 20y ovarian cyst, no smoking. She became menopause in 2014 and noticed dry mouth and oral white coating without pain. She visited at oral surgery of Tsurumi Dental University and was diagnosed as a leukoplakia, following biopsy. Oral and dental examination revealed no evidence of apparent causes and she received dental care, although no efficacy. She visited Keigu clinic, complaining of shoulder stiffness and pain, palpitation and dry mouth in April 2017. Her sex hormone level showed E2 12.0 pg/mL, FSH 83.7mIU/mL, suggesting loss of her ovarian function. Immunological examination showed CRP 0.10mg/dl, RF < 4 and ANA <40. She has no possibility of having autoimmune rheumatic disease. She began receiving HRT and was surprised at disappearing of leucoplakia for 3 months. She keeps in good health until the end of 2018 under HRT receiving.