Imaging of Langerhans Cell Histocytosis in an Adult

Langerhans Cell Histocytosis (LCH) is a rare disease of clonal dendritic cells which may affect any organ of the body. The disease is more common in children aged 0-15 years. It is very rare in adults. The current knowledge about the diagnosis and treatment is mostly based on pediatric studies. Here, I report the case of an adult with multiple bony lesions for which she was referred for palliative radiotherapy for metastatic malignancy of unknown primary. It is paramount to have a tissue confirmation for suspected metastatic cancer with non-confirmed primary.