Management of rare case of mifepristone induced thrombotic microangiopathy

Thrombotic microangiopathies are a group of disorders characterized by microangiopathic haemolytic anaemia, haemolysis , fragmented RBCs and micro vascular thrombosis. Thrombotic thrombocytopenic Purpura is characterized by pentad of fever, thrombocytopenia, microangiopathic haemolytic anaemia, transient neurologic deficit, and renal failure. Haemolytic Uremic Syndrome is also associated with microangiopathic haemolytic anaemia and thrombocytopenia but is distinguished by absence of neurologic symptoms, prominence of acute renal failure and frequently occurs in children. Mifepristone is an anti progesterone indicated for medical termination of pregnancy along with misoprostol up to 49 days of gestational age. We hereby present a case of mifepristone induced Thrombotic microangiopathy which is a rare complication as such in a patient who took MTP drugs over the counter and underwent plasmapheresis.