A Brief Communication on a Cell Line of Neural Stem Cells B50 Cells Treated With a New Cisplatin-Based Drug

The B50 neuronal cell line was derived, in the 1974, from neuroblastoma in the neonatal rat central nervous system (CNS), and to date it's a cell line widely used in different studies. B50 cells offer several advantages to researchers for the study of CNS neurons in culture: they are simple to grow, to differentiate and to transfect. B50 cells have been extensively used in the study of death, toxicology and neuronal cell differentiation. Since 2008, Bottone and collaborators use this model to investigate the effects of cisplatin (cisPt) and new platinum compounds on the stem component of a brain tumour: neuroblastoma. Neuroblastoma is the most common extra-cranial solid tumour in infants and children and accounts for 8-10% of all childhood cancers. It causes the 15% of cancer deaths in the paediatric population. The incidence of neuroblastoma is 10.2 cases per million in children under 15 years of age and almost 500 new cases are reported each year [1].