SYNTHESIS OF NOVEL MANNICH BASES ON THE BASE OF 1-PHENOXY-3-PROPYLTHIOPROPANE-2-OL AND SECONDARY AMINES

The condensation of 1-phenoxy-3-propylthiopropan-2-ol with formaldehyde and secondary aliphatic, as well as heterocyclic amines, has led to the formation of new aminomethoxy derivatives of 1-phenoxy-3-propylthiopropane with 69–77% yields. The physico-chemical parameters of the synthesized compounds were determined, their structure was confirmed by the methods of elemental analysis, IR spectroscopy, 1H and 13С NMR. The compounds obtained were tested as antiseptic substances against bacteria and fungi. It is established that they are more effective than the currently used medical drugs