OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN CHILDREN WITH LEGG-CALVE-PERTHES DISEASE

Background. The main task in treatment for Legg-Calve-Perthes disease in children is search for pathogenetically substantiated approaches, largely dependent on laboratory data. The important role of derangement of blood supply in the development of this disease necessitates study of peroxidation processes and the activity of antioxidant defense enzymes in blood serum of children before the treatment. Aim. Determination of biochemical parameters of peroxidation of lipids, of oxidative modification of proteins and of activity of antioxidant defense enzymes in blood serum of children with Legg-Calve-Perthes disease. Carrying out of comparative analysis in comparison with the normal values of these parameters. Materials and Methods. Parameters of lipid peroxidation and oxidative modification of proteins and the activity of antioxidant defense enzymes were determined in serum samples of 18 patients (8 patients with Perthes disease and 10 patients of the control group). Results. In serum of children with Legg-Calve-Perthes disease, a decrease in the activity of antioxidant enzymes was found, with statistically significant reduction in the activity of superoxide dismutase (SOD). No increase in the content of lipid peroxidation products was found, but redistribution of protein oxidative modification products was revealed with predomination of ketones. Conclusion. In the development of Legg-Calve-Perthes disease, the amount of secondary products of protein peroxidation – ketones – increases, the activity of antioxidant system enzymes is represented by a decrease in catalase activity and by an increase in the activity of SOD enzyme.