ANTIOXIDANT ACTIVITY OF SILVER GLYCONANOPARTICLES BASED ON MERCAPTOPROPIONYLHYDRAZONES OF MONO- AND DISACCHARIDES

Background. It is known that excessive activation of free radical and peroxide reactions is one of the main factors of damage to cell membranes. The enhancement of lipid peroxidation processes is essential in the etiology and pathogenesis of many diseases. In order to protect biological macromolecules from oxidative stress, antioxidants are used. Recently, a number of areas have been developed related to the study of metal glyconanoparticles. These objects are used as immunochemical markers and biosensors in diagnostics and treatment of oncological diseases. Earlier, we showed that silver glyconanoparticles based on mercaptopropionyl-hydrazones of aldoses exhibit antiviral and antifungal activity. Aim. Was to study the antioxidant activity of silver glyconanoparticles based on the condensation products of 3-mercaptopropionic acid hydrazide with mono- and disaccharides. Materials and Methods. The objects of the study were Wistar white rats – 7 batches, 6 rats in each. Introduction of silver glyconanoparticles of 3-mercaptopropionylhydrazones of mono- and disaccharides was carried out daily for 7 days. The test substances were administered per os in 1% starch solution on the basis of 0.1 g per 1 kg of mass. As compounds with antioxidant activity, 6 substances containing residues of D-xylose, L-arabinose, D-lactose, D-glucose, D-maltose and D-mannose were investigated. Sodium diclofenac in 1% starch solution was used as a standard. The control group received only 1% starch solution. Evaluation of the intensity of oxidative modification of proteins (OMP) in the serum was carried out by method of R.L. Levine in the modification of E.E. Dubinina. Results. For the two test substances, a decrease in the spontaneous oxidative modification of proteins was noted compared with the control group treated with sodium diclofenac. An increase in the metal-catalyzed oxidative modification of proteins for the three test substances was observed, which may indicate an increase in the reserve-adaptational potential under their influence. The highest metal-catalyzed activity was found in silver glyconanoparticles based on xylose mercaptopropionylhydrazone. Conclusion. The obtained results showed the possibility of using silver glyconanoparticles based on xylose mercaptopropionylhydrazones for creation of drugs with antioxidant activity.