EFFECT OF FLUMETHRIN ON HEMATOLOGICAL AND BIOCHEMICAL CHANGES IN RATS

The effect of daily oral administration of flumethrin on the blood and tissue enzyme activity in albino rats was investigated. In the present study 12 (6 female and 6 male) rats were used and divided in to two groups. The first group served as the control group; the second group received flumethrin (1% pour on formulation) at dose rate of 2 mg/kg bw orally daily for 14 days. On 15th day, animals were sacrificed and blood and liver samples were collected. Flumethrin neither altered the hemoglobin level significantly nor the blood cell counts of rats. Flumethrin significantly altered the enzymatic activity of serum and liver tissue and also the serum and tissue protein. Flumethrin leads to increased MDA level, SOD and catalase activity in liver and blood samples of rats. The present study suggests that flumethrin is having toxic effect, producing oxidative stress in animal's body.