EVALUATION OF MIMOSINE TOXICITY IN GOAT AND BUFFALO ERYTHROCYTE SYSTEM IN VITRO

Dose and time dependent effect of mimosine in goat and buffalo erythrocyte system in vitro have been evaluated in the present study. The results obtained exhibit that mimosine induces hemolysis in both mode of studies with concomitant increase in cellular methemoglobin and malondialdehyde(MDA) level and depletion of cellular reduced glutathione(GSH) level. Such changes in RBC metabolic profiles are indicative of oxidative stress caused by mimosine. No major species variation was observed in effect of mimosine on erythrocytes in vitro.