Anticonvulsant Activity of Aqueous Extract of Root and Stem Bark of Newbouldia Laevis Seem
Journal: International Journal of Advanced Biological and Biomedical Research (Vol.2, No. 8)Publication Date: 2014-08-01
Authors : N S.A. Igwe; N.N. Nwobodo;
Page : 2448-2452
Keywords : Anticonvulsant; Metrazol; MES test; Newbouldia laevis; Safety factor; Therapeutic index;
Abstract
Objective: Newbouldia laevis Seem, is an ubiquitous perennial plant belonging to the family Bignoniaceae with varying applicability in ethnomedicine. Methods: The anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. Results: Results showed that the LD50 in mice was 489.8mg/kg body weight while 5.6mg/kg body weight protected mice against death due to minimum dose of leptazole which caused 100% mortality. The therapeutic index for N. laevis was 87.2 and its safety factor was 1.5. The extract of N. laevis appears to be more effective against drug-induced convulsion than electroshock seizures because the ED50 in metrazol test (5.6mg/kg body weight was significantly lower than the ED50 in MES test (63.1mg/kg body weight). We conclude that N. laevis is safe and will offer maximal benefit to patients suffering from seizures.
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