PHARMACOLOGICAL CORRECTION OF CRY-OGLOBULINEMIA IN ALLERGIC DERMATOSIS WITH CONCOMITANT CYTOMEGALOVIRUS INFECTION

Cryoglobulinemia is the presence of abnormal proteins in the blood. These proteins thicken in cold temperatures. Cryoglobulins are immunoglobulins. It has not known yet why they become solid or gel-like at low temperatures. When this occurs, these antibodies can cause inflammation and block blood vessels. This may lead to problems ranging from skin rashes to kidney failure. Almost all diseases connected with immune system changes, autoimmune reactions or hypersensitivity, me-tabolism breaks or immunoglobulins synthesis breaks, including allergic dermatitis is followed by cryoglobu-linemia. The aim of our research is to investigate the role of cytomegalovirus (CMV) infection in the cryoglobu-linemic syndrome that accompanied allergic dermatosis and to estimate the effectiveness of specific treatment. Methods and materials. 114 patients aged 18-61 with allergic dermatosis took part in the investigation. Cryoglobulins content was defined with adjusted for immune complexes that circulate in blood and calcu-lated spectrophotometric for the inequality of optical condensations with 500 nm wavelength in 4 and 37°С. CMV presence was proved specific IgM та IgG test in blood serum with the help of enzyme-linked immuno-sorbent assay and DNA CMV by PSA chain reaction method. Pathogenic pharmacotherapy of the main disease was carried out to all patients. It gave the possibility to achieve medical-inductive remission during the investigation. People with concomitant cytomegalovi-rus infection were given additional immunomodulative drug with antivirus activity Inosine pranobex (Groprynosin) in dose 50 mg/kg 30 days and antivirus medicine for inhibiting activity relatively CMV – Acy-clovir 200mg a day, course of treatment was 12 days. Results and discussion. Concomitant CMVI was found in 89 (78.07 %) patients among 114. Cryoglobulins in blood serum were determined in 85 % of allergic dermatosis patients regardless of CMV presence. The highest cryoglobulins content (26.2 % higher) was in patients without CMV, the lowest was in patients with acute CMV infection. The usage of antiallergic treatment in patients without concomitant virus process led to cryoglobuline-mia frequency decrease to 64 %, and its level to 45,8 %. Stable clinic remission has been achieved only in 30 %. In combination of antiallergic treatment with Acyclovir and Inosine pranobex cryoglobulinemia fre-quency decreased for 14.9 % in patients with con-comitant CMV infection, cryoglobulinemia content decreased for 42.0 %. Stable clinic remission has been achieved only in 63.6 %. As a result, basic antiallergic therapy decreases cryoprecipitate formation only in patients without con-comitant virus infection when compliment and activation of mast cells degranulation has pathogenic link. Choosing the cryglobulin treatment tactics antivirus immunomodu-lation therapy plays the main role. All other methods are symptomatic. The allergic dermatosis leads to the development of cryoglobulinemic syndrome in 85 % of patients regard-less of concomitant cytomegalovirus infection presence. The duration of the concomitant viral process affects the level of cryoglobulins (it is the lowest in patients with only anti-CMV IgM). Traditional antiallergic therapy is effective against cryoprecipitation only in patients with-out concomitant viral pathology. However, combination of this therapy with antiviral and immunomodulative medications is effective in concomitant cytomegalovirus infection presence.