Photosensitization of phthalocyanine for singlet oxygen generation in photodynamic therapy applications
Journal: Journal of Medicinal and Chemical Sciences (Vol.3, No. 1)Publication Date: 2020-01-01
Authors : Ali Zare; Mahmoud Mirzaei; Mahboubeh Rostami; Elham Jafari;
Page : 55-59
Keywords : Phthalocyanine; Photosensitizer; Singlet molecular oxygen; Density functional theory;
Abstract
In this work, phthalocyanine and its OCH3 derivatives were investigated to see their photosensitization characteristics for producing singlet molecular oxygen, which is important in photodynamic therapy type-II. All structures were first optimized to achieve the minimized energy 3D models Subsequently, they were prepared for the photosensitization investigations. All the experiments were conducted based on the density functional theory calculations. The energy absorption and emission observed between the occupied and unoccupied molecular orbitals based on the required energy for excitation and the corresponding energy of emission. The results indicated that the OCH3 models could be expected to be safer than the original phthalocyanin by their required energy at longer wavelengths. The ratio of singlet molecular oxygen generation was found to be 1:1 for each of the OCH3 derivatives.
Other Latest Articles
- Medical implementation practice of supramolecular complex of megosin with MASGA
- Microwave-assisted synthesis of phenanthro[9, 10-d]imidazole derivatives under solvent-free and one pot conditions
- Synthesis of icosadeuterio-benzopinacol (benzopinacol-d20)
- Exploring molecular docking and electronic studies of [11C]LY2795050 as a novel antagonist tracer for positron emission tomography (PET) scan of the kappa (κ) and mu (µ) opioid receptors (KOR and MOR)
- Development and Validation of RP-HPLC Method for Simultaneous Estimation of Three Components in cream formulation used in Hemorrhoids Disease
Last modified: 2019-07-27 17:42:18