Use of Laboratory Animals in A Pre-Clinical Trial: A Critical View of the Biomodels Development and Application| Biomed Grid

The scientific use of laboratory animals throughout history demonstrates changes in their vision and applicability, specifically from a moral, ethical and current legislation. In the Laboratory Animal Science Division of the Cellular Biology Laboratory, the development of experimental models and the performance of pre-clinical tests emphasizes the 3Rs principle of refinement in relation to equipment and methodologies. Thus, we transform the point of view over animal model as a Bioreactor for a Biomodel, being able to associate clinical/behavioral methods, consequently, to increase the welfare animal, reproducibility and confiability of the results