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Highly effective synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using pyridinium-N-sulfonic acid bisulfate as a dual-functional catalyst

Journal: Asian Journal of Nanoscience and Materials (Vol.2, No. 4)

Publication Date:

Authors : ; ; ;

Page : 367-375

Keywords : 3; 4-Dihydropyrimidin-2 (1H)-one Acidic ionic liquid Dual-functional catalyst Pyridinium-N-sulfonic acid bisulfate (Py-SO3H][HSO4]) Solvent-free;

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Abstract

Acidic ionic liquid pyridinium-N-sulfonic acid bisulfate ([Py-SO3H][HSO4]) has effectively catalyzed the production of 3, 4-dihydropyrimidin-2 (1H)-ones via the condensation reaction of the arylaldehydes with β-ketoesters and urea under solvent-free conditions. Due to the dual-functionality of [Py-SO3H][HSO4] (bearing acidic and basic sites), it was highly effective and general catalyst for the reaction. Additionally, an attractive mechanism for the dual-functionality of the catalyst was proposed.

Last modified: 2019-08-22 04:30:10