Role of non-HDL cholesterol in type II diabetes mellitus

Introduction: Type 2 diabetes mellitus is a widespread global disorder among which India is the one where 1/3rd of the population suffering from diabetes and majority of them were diagnosed during the complication. Diabetic dyslipidemia is the major contributor for the cardiovascular disease. Measurement of cholesterol level without HDL (total cholesterol minus HDL cholesterol) could be a valuable indicator of this risk. The atherogenic plasma index (AIP) reveals the balance between atherosclerotic and protective lipoproteins {Log (TG / HDLc)} and can also predict cardiovascular risk in patients with type II diabetes mellitus. The main aim and objective of the study is to find out the role of Non- HDL cholesterol in assessing the cardiovascular risk and also atherogenic index of plasma (AIP) ascertained as log (TG/HDL-C) can been utilized as a massive indicator of atherosclerosis and cardiovascular dangers in type II diabetes mellitus. Materials and Methods: Case-control study included 100 (50 men and 50 women) patients with newly diagnosed type II DM in the 32-65 age group as cases and 100 (50 men and 50 women) healthy individuals of the same age group without family history Type 2 DM of the general population as controls. All samples were studied for fasting blood glucose, total cholesterol, LDLc, HDLc and Triglycerides, while non-HDL cholesterol and AIP levels were calculated. Results: The present study showed that there was a significant rise in Non-HDLc (p <0 xss=removed xss=removed>Conclusion: Non-HDL cholesterol and AIP can be used as indicators of diabetic dyslipidemia and also be used to predict the risk of cardiac and vascular disease in type 2 DM.