Immunohistochemistry in breast carcinoma
Journal: Indian Journal of Pathology and Oncology (Vol.5, No. 3)Publication Date: 2018-09-01
Authors : Gireesh V. Achalkar;
Page : 415-417
Keywords : Breast carcinoma; Infiltrating duct carcinoma; Immunohistochemistry (IHC); Estrogen receptor (ER); Progesterone receptor (PR); Human epidermal growth factor receptor-2(HER2.;
Abstract
Introduction: Breast Carcinoma has emerged as most common type of malignant tumor in women surpassing cervical carcinoma which was commonest few decades ago. Hence a proper diagnostic protocol is very much necessary for diagnostic, management and prognostic purposes. Immunohistochemistry has helped to some extent in this aspect. Materials and Methods: Both H&E stained sections and IHC sections for ER, PR and Her2 were studied. The Hormone receptor status was correlated with age, grade and type of tumor. Results: Total cases analyzed in the present study were 50. Infiltrating ductal carcinoma was 45/50(90%) and others were 5/50(10%). IDC was the most common one and triple negative tumors being 34.83% Hormone receptor status was more in younger patients than older ones. And there was positive association with smaller size of the tumors. Their expression was higher in grade I tumors at 85% than in grade III tumors at 10%. The smaller tumors less than 2cm showed triple positively more frequently than larger tumors more than 2cm. Conclusion: In the present study the breast carcinoma in younger patients having smaller size of tumor was frequently positive for ER, PR and negative for Her2/neu than older patients with larger size of the tumor. Immunohistochemical study of breast carcinoma must be routine so as to help the clinician for better management of patients.
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