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Immunohistochemistry in breast carcinoma

Journal: Indian Journal of Pathology and Oncology (Vol.5, No. 3)

Publication Date:

Authors : ;

Page : 415-417

Keywords : Breast carcinoma; Infiltrating duct carcinoma; Immunohistochemistry (IHC); Estrogen receptor (ER); Progesterone receptor (PR); Human epidermal growth factor receptor-2(HER2.;

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Abstract

Introduction: Breast Carcinoma has emerged as most common type of malignant tumor in women surpassing cervical carcinoma which was commonest few decades ago. Hence a proper diagnostic protocol is very much necessary for diagnostic, management and prognostic purposes. Immunohistochemistry has helped to some extent in this aspect. Materials and Methods: Both H&E stained sections and IHC sections for ER, PR and Her2 were studied. The Hormone receptor status was correlated with age, grade and type of tumor. Results: Total cases analyzed in the present study were 50. Infiltrating ductal carcinoma was 45/50(90%) and others were 5/50(10%). IDC was the most common one and triple negative tumors being 34.83% Hormone receptor status was more in younger patients than older ones. And there was positive association with smaller size of the tumors. Their expression was higher in grade I tumors at 85% than in grade III tumors at 10%. The smaller tumors less than 2cm showed triple positively more frequently than larger tumors more than 2cm. Conclusion: In the present study the breast carcinoma in younger patients having smaller size of tumor was frequently positive for ER, PR and negative for Her2/neu than older patients with larger size of the tumor. Immunohistochemical study of breast carcinoma must be routine so as to help the clinician for better management of patients.

Last modified: 2019-09-03 18:34:53