Histopathologic spectrum of adrenal lesions

Introduction: The bipartite adrenal gland has tumors arising from cortex, medulla or as metastasis from extra-adrenal sites. Distinguishing benign from malignant types is a challenging task for pathologists, this study gives an insight into adrenal lesions with their histopathological and immunohistochemical findings and its role in categorizing these tumors to aid in their diagnosis and proper management. Aim: To study the Histopathological patterns of adrenal lesions with clinical correlation. Materials and Methods: In a five year period10 surgical specimens of adrenal tumors were resected and studied between July 2010 to June 2015 at Kamineni Institute of Medical Sciences, Narketpally and King Koti. Tissues were processed and stained sections were studied for histopathological patterns and IHC markers used were vimentin, synaptophysin, NSE, chromogranin immunohistochemistry was done wherever necessary and the markers used were vimentin, synaptophysin, NSE, chromogranin. Result: Out of ten adrenal lesions we have studied, two cases were adrenal cysts,1 three were cortical adenoma, one case is Adrenocortical carcinoma-positive for synaptophysin, vimentin, two cases were neuroblastoma-positive for NSE, chromogranin and synaptophysin and two cases are pheochromocytoma - positive for chromogranin. Conclusion: Pathological evaluation and immunohistochemical profiling has got important role in categorizing adrenal tumors along with clinical, radio logical and biochemical inputs and their subsequent management.