Clinicopathological and immunohistological profile of infiltrating ductal carcinoma breast in a tertiary care centre of western UP- A study of 100 cases

Introduction: Breast cancer is the most common cause of death of women worldwide and it is the most common malignancy in Indian females followed by carcinoma cervix. Diagnosis involves various modalities like clinical examination, radiological investigations, fine needle aspiration cytology (FNAC) and histopathological examination. Recently, immunohistochemistry (IHC), is becoming a standard methodology in pathology laboratories worldwide. IHC provides substantial information with regard to diagnosis, therapeutic prediction and prognosis of breast cancer. Therefore, hormonal studies evaluating the status of estrogen receptor (ER), progesterone receptor (PR) and Human epidermal growth factor-2 (Her2 neu) have become a part and parcel of the histopathology reporting. Materials and Methods: Present study included 100 cases of Infiltrating Ductal Carcinoma (IDC) breast diagnosed in mastectomy specimens received in department to Pathology, Rohilkhand Medical College and Hospital, Bareilly between July 2014 to June 2017. Other histological variants were excluded from the study. Various parameters including age, site, tumor size, lymph node metastasis, histopathological grading, hormone receptor status namely ER, PR and Her2 neu were studied. The histological grade was correlated with the hormone receptor status. Results: Majority patients belonged to the age group of 41-50 years (34%). Most of the carcinomas were of Bloom Richardson grade II (73%). In terms of the IHC profile, majority were ER/PR negative and Her2 neu positive (45%). Conclusion: Breast carcinoma should be studied in all respects in order to understand its behaviour. Additionally, immunohistopathological studies should be carried out in all cases in order to obtain predictive and prognostic information.