A study of coagulation profile in diseases of liver: At tertiary care center hospital

Introduction: The liver is the main site of organ for coagulation system. Liver plays a predominant role in regulation of hemostasis. Hepatic disorders are widely prevalent in tropical countries are responsible for morbidity and mortality. Aims and Objective: The diagnosis of liver diseases by assisting in differential diagnosis with various coagulation tests. In assessment of prognosis of patients of various liver disease. Materials and Methods: The study was conducted in the laboratory of Guru Gobind Singh Hospital, Jamnagar. This study included 100 patients clinically diagnosed with liver disease who were divided into three categories – cirrhosis, viral hepatitis, and obstructive jaundice. The coagulation tests PT, APTT, BT, CT, and platelet count were performed and the results were evaluated in groups. Result: Out of the 100 patients, 40 were diagnosed with cirrhosis, 40 were of viral hepatitis, and 20 were of obstructive jaundice. About 75% (75/100) had prolonged PT. About 39% (39/100) had prolonged APTT. Thrombocytopenia was seen in 58% (138/300) patients.17 cases out of 100 patients (17%) show result of Hypofibrinogenemia. Conclusion: The conclusion of this study reveals various coagulation abnormalities vary with different liver diseases, duration and severity of disorders. In advancing liver cirrhosis, raised level of PT and APTT indicates damage to liver parenchyma resulting in reduced production of coagulation proteins with increased risk of bleeding tendencies which can be detected before these ensue.