Diagnostic efficacy of imprint cytology and frozen section of breast lesions

Objective: To perform imprint cytology of operable breast masses and evaluate its accuracy in relation to histopathological diagnosis after H &E staining and to perform frozen section on operable breast masses and evaluate its accuracy after histopathological diagnosis with H &E staining. Materials and Methods: A total of 82 surgically resected specimens were examined by both imprint cytology and frozen section and compared with histopathological sections which were considered as gold standard. Results: Out of 82 cases 4 taken were inadequate. Total 78 cases subjected to imprint cytology which diagnosed all 43 benign lesions correctly and out of 35 malignant lesions 29 were diagnosed correctly with 6 FN results and no FP results were seen. Imprint cytology showed sensitivity, specificity and accuracy of 100%, 82.86% and 92.31% frozen section diagnosed all 43 benign lesions correctly and out of 35 malignant lesions 33 were correctly diagnosed with 2 FN results and no FP results were seen. Frozen section showed sensitivity, specificity and accuracy of 100%, 94.29% and 97%. Correlation of both imprint and frozen section alone showed 45 benign lesions and out of 33 malignant lesions 29 were correctly diagnosed with 4 FN results and no FP results were seen. Imprint cytology and frozen section combined efficacy showed sensitivity, specificity and accuracy of 91.84%, 100% and 94.87%. Final correlation of both imprint cytology and frozen section with HPE showed significant association. Conclusion: FS is superior to imprint cytology when compared with gold standard HPE in intraoperative diagnosis of breast mass lesions.