The Protective Role of Menthone Against Indomethacin-Induced Gastric Ulcers in Rat Model

Background: The use of novel agents has been considered for management of different diseases. Gastric ulcer is a common disease. This study aimed to evaluate the effects of menthone, as a novel agent, on gastric ulcers in Indomethacin-induced model rat. Methods: Animals were divided into 3 groups: 1) Control group that received only distilled water, 2) Animals were treated with 40 mg/kg bw omeprazole (Omeprazole) and 3) Animals were treated with 40 mg/kg bw menthone (Menthone). A single dose of indomethacin (30 mg/kg body weight) was administrated to per animal. Gastric secretions and antioxidant parameters were evaluated in the end of trial. Results: It was observed that an increased ulcer index, gastric volume, malondialdehyde level and decreased super oxide dismutase and pepsin activity in control group in comparison to other groups (P<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin. Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate effects of indomethacin. We recommend using of menthone, as an efficient agent, for treatment of gastric ulcer.