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Sex-determining region y (SRY)-Box2 (SOX2) & L1-cell adhesion molecule (L1CAM) expressions in endometrioid carcinoma of the uterus; An Immunohistochemical Study
Journal: Annals of Cytology and Pathology (Vol.3, No. 1)Publication Date: 2018-08-09
Authors : Amir M Salem; Entsar R Mahdy;
Page : 001-008
Keywords : Sox-2; L1CAM; Endometrioid carcinoma; Grade; Immunohistochemistry;
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Abstract
Background: activation of cancer stem cells and disturbances in cell adhesion pathways are recently incriminated in endometrioid carcinoma progression, invasion and metastases which consequently leads to dismal patients outcome. Sex-determining region y (SRY)-Box2 (SOX2) is a member of SOX family and it has many roles in malignant stem cells control. L1-cell adhesion molecule (L1CAM) is a membrane glycoprotein which is a member of immunoglobulin family.
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