ESTIMATION OF ANTIPYRETIC, PALLIATIVE AND ANTI-INFLAMMATORY POTENTIAL OF METHANOLIC EXTRACT OF TERMINALIA CATAPPA

In present study, anti-inflammatory, palliative and antipyretic activities of methanolic extract of Terminalia catappa leaves were evaluated in standard experimental models. The results showed that the positive control (Indomethacin) significantly decreased the paw edema at 1 h to 4 h after carrageenan injection compared to saline with 56.31% to 59.85% inhibition rate. A maximum oedema of paw volume 1.42±0.03 mm was observed in the control rats, 4 h after the carrageenan injection. Also tail flick and hot plate models revealed that methanolic extract significantly reduced the painful stimulus. This confirmed the involvement of central and peripheral effects of the extract. The extract also possessed antipyretic potential evidenced by significant induction of pyresis by yeast cell within 3 h. Thus, methanolic extract was found to have wide variety of pharmacological effect in the form of anti-inflammatory, palliative and antipyretic effect which proves the utility of Terminalia catappa in experimental pharmacology of cytokines and prostaglandins (PGs). {*Correspondence to Mr. Saurabh Arjariya, Department of Pharmacology, Sagar Institute of Pharmaceutical Sciences, Narsinghpur Road, Sagar, Madhya Pradesh, India - saurabharjariya@india.com}