DETECTION OF ESBL AND MBL PRODUCING PSEUDOMONAS AERUGINOSA IN TIRUNELVELI MEDICAL COLLEGE HOSPITAL

AIM The present study was done to detect E x t e n d e d s p e c t r u m b e t a l a c t a m a s e a n d metallo-beta-lactamase producing isolates of Pseudomonas aeruginosa from varaious clinical samples from patients admitted in Tirunelveli medical college hospital. MATERIAL AND METHODS In this study we studied the prevalence of ESBL and MBL among 112 Pseudomonas aeruginosa isolates, following standard methods of isolation and identification of these bacteria from clinical materials RESULTS Out of 112 isolates of Pseudomonas aeruginosa, 32 were producing Extended spectrum beta lactamase enzyme producing isolates, 11 isolates were resistance to Imipenem . Of the 11 imipinem resistant isolates, 7 were m e t a l l o - b e t a - l a c t a m a s e e n z y m e p r o d u c i n g isolates. CONCLUSION The present study underlines the unique problem that the presence of ESBL has led to the widespread use of Imipenem which in turn led to the emergence of MBLs .Infection caused by MBL (metallo-beta-lactamase) positive isolates of Pseudomonas aeruginosa is important to identify because it poses not only therapeutic problem due to broad spectrum drug resistance, but also a serious concern for infection control.