Genetic Study in Infertile Male Patients with Asthenozoospermia (AZS)

Purposes: Abnormally low percentage of progressive motile sperms in semen leads to Asthenozoospermia, mainly found in infertile male patients. Although the success rate of Assisted Reproductive Techniques (ARTs) in AZS is better, chromosomal abnormalities in such patients can lead to repeated failures of ARTs. Dermatoglyphics plays role of a diagnostic tool in screening genetically transmitted diseases. So to reduce financial and psychological stress of failure in treatment of infertile patients. study was conducted by doing Karyotyping as well as dermatoglyphics of such infertile male patients with AZS. Method: Karyotypes of 17 infertile AZS male patients along with control were studied using standard methods. Dermatoglyphics were obtained using roller inkmethod, and statistically analyzed. Results: Very high incidence i.e. 70.29 % (12/ 17) of chromosomal aberrations was found in present study mainly in patients with repeated failures in ARTs. Microdeletion on chromosome no. 2 was significant finding along with other numerical as well as structural abnormalities. Dermatoglyphics also revealed statistically significant findings. Conclusion: Chromosomal study in case of infertile male patients with asthenozoospermia proceeding for ARTs can help the treating doctors to decide about the line of treatment and the patients to avoid financial and psychological stress of failure in treatment