ACUTE RENAL FAILURE IN CHOLANGIOCARCINOMA - A CASE REPORT

Acute renal failure occurs in 8-10 percentage of patients requiring surgery for relief of obstructive jaundice leading to eventual mortality of 70-80 percentage. Studies have indicated that the retention of bile during cholestatic jaundice affect the integrity of cardiovascular function by reducing peripheral vascular resistance which results in systemic hypotension, by depressing myocardial performance, by causing profound natriuresis and diuresis that may lead to volume depletion and ultimately result in pre-renal failure. Studies have also demonstrated that kidney functions are affected by causing tubular cell toxicity leading to acute tubular necrosis. The above mentioned complications can be prevented by simple judicious management of the patients preoperatively by adequate hydration and oral bile salts. Herewith is presented a case of cholangiocarcinoma, where the patient developed acute renal failure postoperatively, and was taken up for haemodialysis with very little improvement.