SECRETOR STATUS OF A AND В ANTIGENS IN SALIVA OF HEALTHY VOLUNTEERS

Background. The simplicity and convenience of collecting saliva, as well as its component composition, make this biological fluid a common object for laboratory examinations, in particular for detecting the nucleic acids of viruses and bacteria, and in monitoring certain clinical conditions. The range of clinical situations in which the use of saliva is possible is becoming increasingly widespread and includes determination of the secretor status. Aim. To characterize the secretor status of the saliva depending on the presence of group-specific antigens of AB0 system. Materials and Methods. The study involved 89 healthy volunteers (19% men and 81% women), whose condition was confirmed by the absence of acute and exacerbations of chronic diseases and by the absence of socially significant diseases. The study material was venous blood and saliva. The blood group in AB0 system was determined by the cross-match method, and the secretor status of saliva was determined by Vidas method. Results. In the course of study it was found that among 89 examined individuals, 42.5% had 0 (I) blood group, 31.5% had A (II) blood group, 16.5% had B (III) blood group and 9.5% had AB (IV) blood group, here, 82.7% of participants were Rh-positive and 17.3% – Rh-negative. The presence of antigens A or B in saliva was detected in 44.1% of the participants. 55.9% Of participants did not secrete these antigens. The absence of antigens A and B in individuals with a ‘non-zero' blood group was noted in 13% of participants, 9% of them had B (III) blood group. In 27% of participants antigen A was found in saliva, and in 7.6% – antigen B. 9.5% Of participants secreted both antigens. Conclusion. Antigens of AB0 system are commonly considered in the context of immunohematology and transfusiology, however, recently new data appeared about the significance of their study in saliva. These results are of interest not only for practical medicine as a convenient and non-invasive diagnostic method, but also for salvation of fundamental problems. Determination of the glycome of the patients saliva as an individual parameter of a specific person will help create a new personalized approach in preclinical diagnosis and develop preventive measures for many known diseases.