Correlation of fasting and post meal plasma glucose level to increased HbA1c levels in type-2 diabetes mellitus

Background: Various observational studies and clinical trials have demonstrated that intensive glycemic control prevents the development and progression of long term diabetic micro-vascular complications and may reduce macrovascular complications. However, there is insufficient data to determine the contribution of fasting and post meal plasma glucose to increase the percentage of HbA1C level. Therefore, it is desirable to know whether fasting or post-prandial plasma glucose level alone or in combination will be necessary in adjusting the therapy to achieve optimal HbA1C levels in type-2 diabetes mellitus. The present study was aimed to correlate fasting and post meal plasma glucose level to HbA1C level in type-2 diabetes mellitus. Methods: 50 diagnosed uncomplicated patients of type-2 diabetes mellitus under treatment in diabetic clinic of Acharya Vinoba Bhave Rural Hospital (AVBRH) were enrolled for the study. We have used Pearson's correlation coefficient to find the statistical significance. Results: Both fasting as well as post-meal glucose levels were correlated with HbA1C but higher correlation was seen between fasting plasma glucose and HbA1C. Conclusion: Our study revealed that fasting plasma glucose value appreciably contributes HbA1C as compared to post-meal glucose values.