Antiulcer Activity of Annona Squamosa Seed Extract in Experimental Rats

Antiulcer activity of aqueous extracts of Annona squamosa seed extract was studied in Rats by pyloric ligation method. The extract at dose of 100,200 mg/kg produced significant inhibition of gastric lesion induced by Pylorus ligation induced ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The results indicate that the alcoholic extract significantly (P < 0.001) decreases the volume of gastric acid secretion, PH, free acidity, total acidity and ulcer index with respect to control.