RISK FACTORS FOR BREAST CANCER RECURRENCE : ABOUT 310 CASES

Purpose: To retrospectively study our risk factors for breast cancer recurrence and compare them with data from the literature. Materials and Methods: Through the analysis of 310 patients admitted to the radiotherapy department of the Mohammed V Military Teaching Hospital in Rabat between January 2009 and December 2015, we identified local, locoregional and / or systemic recurrence factors. Results: The mean age was 49.15 ? 10.37 years, the mean parity was 3.3 ? 2, 43.5% were postmenopausal, 18.3% had a family history of breast cancer, and 41.3% used oral contraception. According to the TNM classification, 49.8% were classified as stage IIA. Invasive ductal carcinoma was predominant (82.6%). For the histo-prognosis grade of Scarf-Bloom and Richardson (SBR), 91% of patients were classified as SBR II and III. Lymphovascular invasion (LVI) were positive in 44.2%, and hormone receptors (HR) were positive in 75.8%. Lymph node involvement ≥4 nodes was noted in 28.5% of patients. In univariate analysis, the presence of LVI (p <0.001), N≥4 (p <0.025) and RH negative (p <0.021) were statistically significant risk factors for recurrence. While in multivariate analysis, only EV (p <0.035) and HR negativity (p <0.012) were statistically significant. Conclusion: Our study highlights known risk factors namely massive ganglionic invasion, lymphovascular invasion and hormone receptors. Other factors must be studied to improve the future management of our patients.