To Study the Synthesis and Biological Activity of Thiosemicarbazone2-Benzoylpyridine Schiff’s Base ligand and Its Cu (II) Transition Metal Complexes

Objective: The objective of this study is to synthesize Schiff's base ligands of thiosemicarbazone2-benzoyalpyridine and their copper complexes and study their antimicrobial activity. Materials and Method: Thiosemicarbazone2-benzoylpyridine Schiff's base ligand was prepared by reflux method by using ethyl alcohol as solvent for 7– 8 hrs. Ligand under study was found to be highly soluble in water, and its complexes were prepared in water. PH was adjusted as per the requirement in each case (approximately 6 -7). Round bottom flask (100 mL), condenser, and heating mental were used as apparatus. Result: The complexes of Cu(II) having the general composition CuL2X2 (where L = 2-benzoylpyridine thiosemicarbazone and X = Cl- , NO3 - , ½SO4 2- ) have been synthesized. The complexes of Cu(II) under study were characterized by IR, elemental analysis, magnetic susceptibility, UV, molar conductivity, mass spectrometry, and electron EPR spectral studies. Molar conductance value was calculated using DMSO as solvent. The magnetic moment indicates that all the complexes were of high spin type. On the basis of spectral studies, an octahedral geometry has been proposed for Cu (II) complexes. The complexes under study were screened for antifungal (i.e., Candida krusei and Candida parapsilosis) and antibacterial (i.e., Escherichia coli and Staphylococcus) activities. Conclusion: The synthesized ligand was bidentate and their complexes were found more active toward antimicrobial activity than ligands.