CHANGES OF PRO- AND ANTIOXIDANT STATUS IN THE BLOOD AND HEART OF HIGH- AND LOW-EMOTIONAL RATS IN ETHANOLIC HEPATITIS

Alcohol abuse is one of the oldest and most common social disasters. Contrary to the intensive study of the pathogenetic features of the occurrence of toxic damage to the liver of alcoholic origin, this problem remains relevant today. Among the population, there are people with different tendency to develop alcoholic liver disease, which depends not only on the speed of metabolic processes, but also on the psychological characteristics of the person. The connection between psyche and somatics is two-sided: mental disorders affect somatic functions, and somatic illnesses, in turn, affect the state of the psyche. Identifying the damaging effects of ethanol on the liver and heart in animals with different reactivity can help to develop new treatments and prevention of alcohol and organ damage. The purpose of the study was to evaluate the status of the prooxidant and antioxidant system in ethanol hepatitis in the heart and blood of high- and low-emotional male-rats. The experiments were performed on 36 high- and 36 low-emotional male outbred rats of 5.5-6 months old. Animals are divided into three groups - control 1 (C1), control 2 (C2) and ethanol hepatitis. The emotionality of rats was determined by the method of "open field". The activity of superoxidedismutase (SOD), catalase (Cat), diene (DC) and triene (TC) conjugates were determined in serum and heart homogenates. The activity of alanineaminotransferase (ALT), aspartateaminotransferase (AST), alkalinephosphatase (AP), glucose content and total protein were determined in serum to confirm the development of ethanol hepatitis. Results. Control (intact) low-emotional rats had a higher DC content in the heart, a lower content of Cat in the blood, and a higher in the heart, a lower blood glucose content, compared to high-emotional rats, which indicates a more intense metabolism in the low-emotional rats. Seven-day glucose uptake in all animals resulted activation of lipid peroxidation and antioxidant processes (DC content in the heart was higher in low-emotional rats), decrease in ALT and protein activity; in high-emotional rats was increase AP activity, and in low-emotional rats – glucose. ALT remained at the control level (higher in low-emotional rats). The obtained data indicate liver dysfunction, which is more in high-emotional rats, and heart disturbance, which is more in low-emotional rats. In ethanol hepatitis, activation of lipid peroxida-tion processes in serum (DC was more in low-emotional rats) and heart homogenate (TC was more in low-emotional rats) was noted. At the same time, the activity of the antioxidant system increased. All animals have increased AP and glucose level. The results indicate liver and heart damage, which is more pronounced in low-emotional rats. Ethanol hepatitis in high- and low-emotional rats was accompanied by inhibition of the protein-synthesizing function. As a result, the activity of ami-notransferases decreased. Conclusions. In ethanol hepatitis, activation of lipid peroxidation processes in blood serum) and heart homogenate more in high-emotional rats was noted; the activity of the antioxidant system increases. Alkaline phosphatase and glucose are increased in all animals. Ethanol hepatitis in all rats inhibits protein-synthetic function. Modeling ethanol hepatitis in rats with different emotions causes damage to the animal body by the oxidation mechanism. In this case, liver function is more impaired in high-emotional rats, and heart damage - in low-emotional animals.