ROLE OF MUTATION OF INSULIN RECEPTOR GENES IN THE DEVELOPMENT OF THE PHENOMENON OF INSULIN RESISTANCE

The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity of receptors), glucose transport (reduced number of GLUT4 molecules), and post-receptor (signal transmission disorders) level. The article analyzes the signaling pathway of insulin, and considers the effect of gene mutations on signal transmission and glucose transport to the cell.