SYNTHESIS AND EVALUATION OF SOME NEW SULPHUR, NITROGEN AND OXYGEN CONTAININGHETEROCYCLE THIADIAZOLOTRIAZOLE FOR ANTIBACTERIAL, ANTIFUNGAL & ANTITUBERCULAR ACTIVITY

Thiadiazoles are synthesized by using aromatic acids and thiosemicarbazide. Schiff base reaction isfollowed and then thiadiazolotriazole derivatives are prepared by using hydrazine hydrate, isoniazid andunhydrous FeCl3. All the synthesized compounds were characterized by IR, 1H-NMR and CHN analyses.All the compounds were evaluated for antibacterial, antifungal & antitubercular activity. Compounds A1,B1, C1 and C4 have shown promising antibacterial activity, compounds A3, A4, B4, C2 and C4 have exhibitedexcellent antifungal activities, while compounds A2, A4, B2, B4, C2 and C4 showed anti-tubercular activity.