UV SPECTROPHOTOMETRIC ESTIMATION OF ACETAZOLAMIDE BY STANDARD CALIBRATION CURVE METHOD AND ITS VALIDATION

The proposed UV spectrophotometric method for estimation of acetazolamide is based on the official method for dissolution of acetazolamide tablets mentioned in the United States Pharmacopoeia XXXII.The monograph, however, does not provide basis for estimation of acetazolamide in the bulk drugs by UV spectrophotometric method. Hence a simple, quick and economic method was developed and validated for estimation of acetazolamide in the bulk drug and its dosage forms. This method may be adopted for routine quality control of acetazolamide in bulk drugs and in finished dosage forms.