A PROSPECTIVE STUDY ON CLINICAL PROFILES OF ALCOHOLIC LIVER DISEASE IN A TERTIARY CARE HOSPITAL

Background: There is a significant correlation in development of alcoholic liver disease with type of alcoholic beverage consumed. Country made alcoholic beverage showed a significant development of complications i.e. ascites and encephalopathy and poor prognosis[1]. Objective: To study on Clinical profiles of Alcoholic Liver Disease in tertiary care hospital. Method: A hospital based observational, Prospective study on clinical profiles of ALD in tertiary care hospital for 6months duration in General medicine Department. Based on diagnosis, the study population was interviewed after obtaining written informed consent for assessing the severity, its treatment response, complications and prognosis of ALD using laboratory parameters. Results And Discussion: In this prospective study, the clinical profiles of Alcoholic liver diseases in a tertiary care hospital was evaluated and determined in sixty patients. Among Sixty patients of ALD 95% patients were male and 5% patients were female. The most common age group was between 36-45yrs. Almost 50% of patients with ALD consume 90ml of Alcohol on daily basis. ALD positive were treated majorly with Ursodeoxycholic acid,L-Ornithine L-Aspartate,Thiamine,Chlodiazepoxide, Rifaximin and Thiamine. majority of patients had MELD score ranging between 10-19.Patients were monitored regularly and scores were recalculated accordingly. Conclusion: Management of ALD relies on abstaining from alcohol while treating alcohol withdrawal, providing nutritional support, and managing cirrhosis-related complications. Patients with severe alcoholic hepatitis who fail medical therapy have very poor outcomes. Ascites has been the major complication of Alcoholic liver disease. spironolactone is the drug of choice for the initial treatment. Ursodeoxycholic acid was used in most number of patients(53.33%) in treatment followed by thiamine (31.66%). MELD score will be useful as a template to improve upon as an objective gauge of disease severity and assess risk of mortality.