INSULIN SECRETAGOGUE POTENTIAL OF FERONIA ELEPHANTUM FRUIT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Methanol extract of Feronia elephantum fruit at a dose of 400 mg/kg twice a day, was evaluated for its insulin secretagogue potential in streptozotocin (STZ) 50 mg/kg induced diabetic rats. Treatment showed significant (P<0.001) decrease in blood glucose and significant (P<0.001) increase in seruminsulin, hepatic, muscle glycogen content and restoration of disturbed dyslipidemia. Result obtained from the present study indicates that methanol extract of Feronia elephantum fruit has insulin secretagogue potential in STZ induced diabetic rats.