A FACILE SYNTHESIS OF MUTUAL PRODRUG OF DICLOFENAC SODIUM AND PARACETAMOL AND ITS PREFORMULATION STUDIES

Mutual prodrug was synthesized by esterifying diclofenac with paracetamol. In vitro hydrolysis of prodrug in HCl buffer (pH 1.2) and phosphate buffer (pH 7.4) showed that the drug was released more in pH 7.4. The purity of the prodrug was confirmed by TLC and characterized on the basis of IR spectroscopy and 1H NMR spectroscopy. The physiochemical parameters were determined and the results showed that they are more lipophilic than the parent drug. The compound was also evaluated for anti-inflammatory and ulcerogenicity.