QUANTITATIVE DETERMINATION OF DEFERASIROX IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROPHOTOMETRIC METHOD
Journal: Indian Drugs (Vol.50, No. 2)Publication Date: 2013-02-26
Authors : Marathe G. M. Pande V. V. Patil P. H. Mutha R. E.; Bari S. B.;
Page : 27-32
Keywords : *E-mail: drvishalpande@gmail.com;
- QUANTITATIVE DETERMINATION OF DEFERASIROX IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROPHOTOMETRIC METHOD
- STABILITY INDICATING UV-SPECTROPHOTOMETRIC METHOD FOR SECNIDAZOLE IN BULK AND PHARMACEUTICAL FORMULATION
- DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF APIXABAN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
- DEVELOPMENT AND VALIDATION OF ZERO ORDER DEIVATIVE BY UV- SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DILTIAZEM HCL IN BULK AND ITS FORMULATION
- Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Tenoxicam in Bulk and Pharmaceutical Dosage Forms
Abstract
A simple, fast and reliable zero order spectrophotometric method was developed for determination of deferasirox in bulk and pharmaceutical dosage forms. Beer's law was obeyed in concentration range of 2–12 µ/ml deferasirox at 245.6 nm wavelength. The correlation coefficient was found to be (r2 = 0.999), precision (repeatability % RSD 1.29), percentage recovery 100.054±0.271. The detection limit (DL) and quantitation limit (QL) were 0.247 µg/ml and 0.75 µg/ml respectively. The proposed method was found to be simple, accurate, precise, reproducible and gave an acceptable recovery of the analyte, which could be directly and easily applied to analysis of bulk and pharmaceutical tablet formulations of deferasirox.
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