IMMUNOMODULATORY ACTIVITY OF METHANOLIC EXTRACTS OF SEEDS AND BARK OF PONGAMIA GLABRA VENT. ON HUMAN NEUTROPHILS

Methanolic extracts of seeds and bark of Pongamia glabra Vent. (250 mg/kg and 500 mg/kg p.o.) in the concentration range 100, 50, 25, 12 and 6.25 µg were subjected to evaluate the phagocytic effect on human neutrophils using the in-vitro models – nitroblue tetrazolium (NBT) dye test, phagocyotosis of Candida albicans and chemotaxis assay. The extracts of the plant in the concentration range 100,50,25,12 and 6.25 µg showed significant (P <0.01) phagocytic effect on human neutrophils in the parameters studied. Methanolic extracts of seeds and barks of Pongamia glabra Vent. exhibited immunostimulant property in in-vitro models.