A METHOD FOR PREPARATION OF DROSERONE FROM PLUMBAGINJournal: Indian Drugs (Vol.50, No. 5)
Publication Date: 2013-05-28
Authors : Ferreira G.M.; Laddha K.S.;
Page : 53-56
Keywords : *E-mail: email@example.com;
Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.
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