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A METHOD FOR PREPARATION OF DROSERONE FROM PLUMBAGIN

Journal: Indian Drugs (Vol.50, No. 5)

Publication Date:

Authors : ; ;

Page : 53-56

Keywords : *E-mail: galvinaferr@gmail.com;

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Abstract

Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.

Last modified: 2020-05-28 20:31:09