Comparative Assessment of Topical Formulations by Performing Transmembrane Diffusion and Permeation Using Diffusion Cells

Skin penetration of a drug and the effect of formulation additives can be evaluated by performing diffusion studies. In the present study semisolid cream formulation comprising of bacteriostatic antibiotic of 2 different creams have been compared for the penetration of drug. Based on these in vitro release findings, conclusions were drawn regarding performance characteristics of the pharmaceutically equivalent formulations.