A Review on Mouth Dissolving Tablets

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and thefield has become a rapidly growing area of research in the pharmaceutical industry. Upon introductioninto the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water foreasy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulationresulted in development of several MDT technologies. This review describes various formulations andtechnologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular,this review describes in detail MDT technologies based on lyophilization, moulding, sublimation andcompaction, as well as approaches to enhance the MDT properties, such as spray drying, moisturetreatment, sintering, and use of sugar-based disintegrants.