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SYNTHESIS OF SOME NOVEL 1,2,4-TRIAZOLE ANALOGUES AS POTENTIAL ANTI-TUBERCULAR AGENTS

Journal: Indian Drugs (Vol.51, No. 1)

Publication Date:

Authors : ; ;

Page : 41-47

Keywords : *E-mail: rakeshrsomani@gmail.com;

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Abstract

A series of 5-(N-substituted carboxamidoethylthio)-3-(3'pyridyl)-4-amino-1,2,4-triazole derivatives (6a-j) were synthesized and evaluated for anti-tubercular activity. The derivatives were purified and structures were elucidated by spectral and elemental analyses. They were screened in-vitro at 10µg/mL concentration against Mycobacterium tuberculosis H37RV (ATCC 27294). Compounds 6e and 6h were found active as they exhibited IC50 and IC90 values at < 100µg/mL.

Last modified: 2020-06-01 19:25:58