FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF ATENOLOL USING CHITOSAN
Journal: Indian Drugs (Vol.51, No. 4)Publication Date: 2014-04-28
Authors : Kamble M. D. Dhokchawle B. V.; Tauro S. J.;
Page : 36-41
Keywords : *E-mail: milind_kumar7@rediffmail.com;
Abstract
The effect of various concentrations of chitosan as a polymer was investigated for the transdermal delivery of atenolol across human cadaver skin by using dimethylsulfoxide as a penetration enhancer. Atenolol-chitosan matrix type patches were formulated using different polymer concentrations. Atenolol at a fixed concentration of 10 mg was added in polymer and dibutyl phthalate, 30% w/w of polymer, was added as a plasticizer. All the transdermal patches were evaluated for thickness, weight variation, folding endurance, breaking force, and percent moisture content. The comparative study of release kinetics with different polymer ratios showed that the patch containing drug polymer ratio 1:7 had maximum release of drug (81.92%) and all its physicochemical parameters were within the acceptable limit.
Other Latest Articles
- CYTOMORPHOLOGICAL AND PHYTOCHEMICAL ANALYSIS OF ABRUS PRECATORIUS LINN
- DEVELOPMENT OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN COMBINED DOSAGE FORM
- Publication activity of Russian researchers: academic science
- PEGYLATION: CONCEPT AND APPLICATIONS IN CANCER THERAPEUTICS
- The results of monitoring of Russian core shared research facilities and unique scientific installations for 2015
Last modified: 2020-06-09 19:48:51